skin rash or itching. When used orally at appropriate doses, folic acid is likely safe.Oral use of folic acid can cause: 1. Therefore, people experiencing symptoms like weakness, fatigue, difficulty concentrating, and shortness of breath may benefit from getting their B12 levels checked. Vitamin D 50,000 Units Side Effects Learn More Aside from potential skin rashes, taking large dosages of folic acid can cover up a vitamin B-12 deficiency because the two vitamins have overlapping functions. Hardly anyone talks about folic acid side effects. Zinc Deficiency: The excess consumption of Folic acid create some problems in the gut and this reduces the level of Zinc intake in the person. general weakness or discomfort. Your body breaks down and absorbs folate and folic acid in slightly different ways. Last updated on Oct 11, 2020. Along with its needed effects, folic acid may cause some unwanted effects. Certain minerals may also cause serious overdose symptoms if you take too much. Long-term vitamin B12 deficiency can lead to problems like anemia, fatigue, nerve damage and even neurological changes. You're unlikely to get side effects with folic acid, but some people feel sick, lose their appetite, get wind or feel bloated. Folic acid is the synthetic form of vitamin B9, a B vitamin that plays an important role in cell and DNA formation. Folic acid, otherwise referred to as folate or B9, and vitamin D are two essential vitamins for good health. Thus, anyone taking medications should consult a health professional before taking folic acid (1). Megaloblastic anemia is a blood disorder marked by the appearance of very large red blood cells that crowd out healthy cells, causing anemia. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This medication contains 2 ingredients: vitamin D and folic acid. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Folic Acid (folic acid)." O 0. Toxicity caused by the drug methotrexate. A folate deficiency can lead to complications, especially in pregnant women. Side effects of multivitamin (Vitamin B12, B6, and Folic Acid) consumption [Ref], Frequency not reported: Bitter or bad taste, altered sleep patterns, difficulty concentrating, overactivity, impaired judgement, increased incidence of seizures in some epileptic patients[Ref]. 2. Folic acid’s role in cancer appears to be twofold. Both are important for pregnancy. [Ref], Frequency not reported: Decreased diphenylhydantoin serum levels[Ref], Irritability, excitement, mental depression, and confusion were reported in patients taking 15 mg folic acid daily for 1 month. The rest requires the help of your liver and other tissues to get converted via a slow and inefficient process (8). Folic acid is a B vitamin, and according to Elson Haas in his book “Staying Healthy With Nutrition,” a deficiency in folic acid may be the single most common vitamin deficiency. Irritability 6. Trouble sleeping: Sleeping disorders can occur in person due to many reasons but it can be a side effect of taking too much Folic acid. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Discover the symptoms, how to treat it, and more. Low blood levels of folate have been linked to health issues, such as a higher risk of birth defects, heart disease, stroke, and even certain cancers (2, 3, 4, 5, 6). Vitamin B12, B6, and Folic Acid supplements . Folic acid is important in the embryonic development of the central nervous system. Even the rare side effects of taking too much are minimal. Folic acid supplements are used to reduce the risk of birth defects, as well as prevent or treat a folate deficiency. That said, research is mixed. Folate, or as its synthetic version is called, folic acid, is a water-soluble B vitamin. The Reference Daily Intake (RDI) for this vitamin is 400 mcg for most adults, though pregnant and breastfeeding women should get 600 and 500 mcg, respectively (1). Furthermore, other research ties excessive use of folic acid supplements to mental decline (20). Folic acid and folate are two forms of vitamin B9. 3. Redness 4. In certain countries, some foods are also fortified in this vitamin. However, high doses of folic acid can result in diarrhea, insomnia, rash, etc. Available for Android and iOS devices. Taking doses of folic acid higher than 1mg can mask the symptoms of vitamin B12 deficiency, which can eventually damage the nervous system if it's not spotted and treated. Increased seizure incidence was seen in some epileptic patients receiving phenobarbital, primidone, or diphenylhydantoin. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. 6 Effects of Folic Acid on the Brain. respiratory difficulty due to bronchospasm. Folic acid supplements can be purchased without a prescription and are generally considered safe when taken in normal doses (37). tightness in chest. Methotrexate is a common treatment for rheumatoid arthritis (RA) that can lead to folate deficiency. For instance, research suggests that people previously diagnosed with prostate or colorectal cancer who supplemented with more than 1,000 mcg of folic acid per day have a 1.7–6.4% higher risk of the cancer recurring (33, 34). The unlikely, minor side effects that can occur are as follows: Nausea; Cramps; Irritability; Confusion; Stomach ache; Diarrhea; Skin rash Folic acid deficiency anemia is caused by having too little folate (vitamin B9) in your blood. [Ref], Rare (less than 0.1%): Allergic responses (including erythema, skin rash, itching, general malaise, respiratory difficulty due to bronchospasm), anaphylaxis (including shock)[Ref], Frequency not reported: Decreased vitamin B12 serum levels, worsening symptoms of B12 deficiency[Ref]. Check with your doctor as soon as possible if any of the following side effects occur while taking folic acid: Applies to folic acid: compounding powder, injectable solution, oral tablet, Rare (less than 0.1%): Mild gastrointestinal upset, nausea, abdominal distension, flatulence[Ref], Nausea, abdominal distension, and flatulence were reported in patients taking 15 mg folic acid daily for 1 month. If you experience any side effects related to folic acid or B12, contact your health care professional immediately. However, supplementing with too much folic acid may increase insulin resistance and slow brain development in children. Anorexia was reported in patients taking 15 mg folic acid daily for 1 month. Keep in mind that eating lots of folate-rich foods does not appear to increase cancer risk — and may even help reduce it (35, 36). That said, excess folic acid supplement intake may cause several side effects, including slower brain development in children and accelerated mental decline in older adults. It’s found exclusively in vitamins and certain fortified foods. Conversely, vitamin B9 is called folate when it occurs naturally in foods. Taking folic acid seems to reduce nausea and vomiting, which are possible side effects of methotrexate treatment. Warning signs of an allergic reaction include: 1. Vitamin B12 Deficiency . Folate is the essential vitamin sometimes referred to as Vitamin B9, but more commonly known by its synthetic supplemental form 'folic acid'. Your body uses vitamin B12 to make red blood cells and keep your heart, brain, and nervous system functioning optimally (18). This is concerning because high levels of UMFA appear to be linked to various health concerns (1, 11, 12, 13, 14, 15, 16, 17). Excessive folic acid intake can cause UMFA to build up in your body, which may lead to detrimental health effects. We comply with the HONcode standard for trustworthy health information -, Vitamin/Mineral Supplementation and Deficiency. Information -, Vitamin/Mineral supplementation and deficiency is common taken in large doses greater of! Body uses folate and folic acid supplement intake may speed age-related mental (! Down and absorbs folate and folic acid is basically nontoxic in humans, some side longer... How much you ’ ll need healthy foods that are high in folate ( vitamin is..., Vitamin/Mineral supplementation and deficiency reported in patients taking 5 or 15 mg folic acid supplements mental. In people with a history of cancer and produce red blood cells that crowd out healthy cells causing... 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